Scientists discovered that senescent so-called zombie cells play varied roles in the body, with some protecting tissues rather than causing damage.
Senescent cells stop dividing but remain metabolically active, secreting signals that affect neighboring cells.
Previous anti-aging research often treated all senescent cells as harmful targets for elimination.
The new findings reframe strategies that aim to clear zombie cells indiscriminately.
Some senescent populations appear to support wound healing and limit excessive tissue remodeling.
Others contribute to inflammation and age-related disease when accumulated in large numbers.
Researchers used genetic tools to distinguish beneficial from harmful senescent cell types.
Anti-aging medicine has invested heavily in drugs called senolytics designed to destroy senescent cells.
The discovery suggests selective rather than blanket removal may produce better outcomes.
Further work will map which senescent cells should be preserved at different life stages.
Created by Ayen Stabel.
Stabel is AI and can make mistakes.
Sources:
https://www.sciencedaily.com/