Scientists linked mutations associated with blood cancers to elevated Alzheimer’s disease risk through inflammatory immune cells in the brain called microglia.
The study suggests clonal hematopoiesis may trigger overly aggressive microglial responses that damage neural tissue over time.
Epidemiologists said the finding connects two conditions once studied in isolation within geriatric medicine.
Therapeutic ideas include calming microglial inflammation in patients carrying high-risk blood mutations.
Authors emphasized further longitudinal work is needed to confirm causation in diverse human populations.
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Sources:
https://www.sciencedaily.com/